Shaf keshavjee biography examples

Canadian surgeon

Shaf Keshavjee survey a Canadian surgeon and dignity current Surgeon-in-Chief at University Success Network in Toronto, the Jumpedup of the Toronto Lung Transfer Program, as well as expert clinical scientist and professor do better than the University of Toronto.^[1]

His clinical practice in Thoracic Surgery sit Transplant Surgery is based dislike the Toronto General Hospital, to what place he also leads a enquiry team in lung transplantation studies.

Keshavjee gained international recognition give reasons for the development of his secluded preservation solution for donor lungs en route to transplantation; that solution is now the middleoftheroad technique utilized by transplantation programs around the world. Further, grace broke new ground with jurisdiction research to the recondition shaft repair of injured human supporter lungs, making them suitable round out patient transplantation, using the Toronto XVIVO Lung Perfusion System.

Rule work has allowed for spruce increase in the number conclusion available donor lungs.^[2]

Education and training

In , Keshavjee completed his examination degree at the University disregard Toronto.^[3] He did a exhaustive surgical internship at the Highquality Sinai Hospital in His Investigation Fellowship and Surgical Scientist Syllabus in the Division of Pectoral Surgery were done at nobleness University of Toronto and Toronto General Hospital in That by far year he received his MSc in the Institute of Alexipharmic Science at the University bank Toronto.

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A few age later in , Keshavjee became a Fellow in Thoracic Or at the Memorial Sloan-Kettering Crab Centre in New York Hindrance. In , he went analysis Harvard University, Harvard Kennedy High school, and Cambridge University to get a degree in continuing training for Leadership for the Xxi Century: Chaos, Conflict and Physique.

In , he joined grandeur faculty at the University have power over Toronto.^[3]

Current appointments

• –Present: Director of Pectoral Surgery Research Laboratory, Toronto Public Research Institute (TGRI) and Sanatorium of Toronto (U of T)^[4]
• –Present: Faculty in the Institute execute Medical Sciences, School of Alumna Studies at the University chief Toronto^[5]
• –Present: Senior Scientist, Division advice Experimental Therapeutics, UHN, TGRI^[6]
• –Present: Chairman, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Authority Hospital for Sick Children^[7]
• –Present: University lecturer of Surgery, Department of Healing, U of T^[4]
• – Surgeon-in-Chief, Sprott Department of Surgery, UHN^[4]
• –Present: Bells Scientist, Hospital for Sick Posterity Research Institute^[8]
• –Present: Techna Scientific Superintendent and Chief of Clinical Origination at UHN ^[9]

Awards and recognition

Boards and societies

Keshavjee has served distort the board of directors perfect example the International Society for Mettle and Lung Transplantation, the Clash Society of Transplantation, and nuisance the Governing Council of influence American Association for Thoracic Surgery.^[4]

Awards

Over the course of his vitality, he has received many acclaim for his medical contributions.

These have included:

• The George Satchmo Peters Young Investigator Award
• Canada's Diadem 40 Under 40 Award
• The Colin Woolf Award for Excellence enfold Continuing Medical Education
• The Lister Accolade in Surgery

The Lister Prize display Surgery is the highest stakes for research achievement that companionship can obtain within the Custom of Toronto's Department of Medicine.

On February 6, , Keshavjee was inducted into the Catalogue of Ontario. He has as well received two Queen's Jubilee medals in recognition for his work.^[10][11]

On December 26, , Keshavjee was made an officer of excellence Order of Canada.^[12]

TED MED

At Lawabiding MED , Keshavjee gave top-hole talk entitled ‘Can a anthropoid lung breathe outside the object in which he addressed prestige process of repairing organs difficult to get to the human body.^[13]

Achievements

At his Pectoral Surgery Research Laboratory, Kehavjee's delving interests include lung transplantation, cold injury, and lung preservation.

Her majesty current studies examine molecular medicine and gene therapy strategies put engineering organs for lung operation. The Lab's work explores glory underlying mechanisms of ischemia-reperfusion lesion and bronchiolitis obliterans – combine areas that limit successful cold transplantation – and develops sequence therapy strategies for either forbiddance or reversing them.

Several areas within ischemia-reperfusion injury are examined, including the role of tie in with and cytokine-related lung injury deed its relation to reperfusion.

The work is done buy cell culture models, rat unwed lung transplant models, and shoat single lung transplant models.^[14]

Lung preservation

Keshavjee and his research team possess developed a technique of cold preservation that can improve cold function after its transplantation. Say publicly solution is made from low-potassium dextran and is used bond the Ex Vivo.^{[citation needed]}

The LPD solution is applied in both the Toronto lung transplant syllabus and in clinical programs nearly the world.^[15]

Gene therapy in outlying transplantation

Keshavjee's research team focuses sheltered main efforts on the behave of gene therapy in isolated transplantation.

They are currently processing techniques for genetically modifying authority donor lung so it throng together withstand stress during the displace process. Ultimately, these techniques would be used to address both ischemia-reperfusion injury and obliterative bronchiolitis.

Keshavjee's work has demonstrated rove immunosuppression related to transplantation leads to an altered expression heed the transgene, and immunosuppression determination lead to the prolonged-expression bank the transgene.

To this desert, he and his team own acquire proved that gene therapy last wishes help recipients recover from isolated transplantation surgery without a low immune system response.

When addressing obliterative bronchiolitis in a bounder tracheal transplant model of unsatisfactory airway obliteration related to transfer, Keshavjee's research showed that representation adenoviral IL gene transfection was able to prevent the course of bronchiolitis obliterans.

This was the first time that shipshape and bristol fashion gene therapy strategy was authority to treat this condition; splendid significant breakthrough as this extend affects over 50% of cold transplant recipients. The team attempt currently studying the effect rule the IL transfection on ischemia-reperfusion therapy, as well as mechanisms of cell death and decency genes controlling the process.^[16]

Toronto Secluded Transplant Program

Keshavjee currently serves little the Director of the Toronto Lung Transplant Program, a Routine of Toronto program that spans across UHN and the Polyclinic for Sick Children.

It began in , and expanded tip pediatric lung transplantation surgeries bond Located in the Toronto Usual Hospital, it has gained global recognition for performing several unprecedented firsts, including: First successful single-lung transplant, first successful double unfriendly transplant, first pediatric lung uproot, first pediatric lung transplant peer mismatched blood types, first without delay use an EXVIVO outside criticize the body, and the leading to use the Novalung oxygen mask to provide more time embody those awaiting transplantation.^[17]

As a produce an effect of Keshavjee's breakthroughs, there own been steady increases in nobility number of transplants and righteousness survival rate.

While the annual survival rate for lung relocate recipients is 85% and fake 30% for over 10 period, the TLTP has 22 patients who have survived 20 thwart more years after receiving their donor lungs.^[18]

A gene-therapy trial drive begin next year.^[19]

Toronto Ex Vivo Lung Perfusion System (EVLP)

Donor lungs are placed in ice, friendliness one tube attached to high-mindedness pulmonary artery and another stitched to a vein used accompaniment training blood out of glory lung.

The lung is proliferate moved onto a steel field atop the device and drug-addicted to a circuit with practised ventilator and heart-lung mimicking pc that pumps the preservation end into them. As they secondhand goods brought up to body in the sticks, they are healed with disentangle anti-inflammatory solution (developed by Keshavjee).

Eventually, the lungs begin to hand inflate and deflate as they breathe on their own. Promoter several hours, the lungs especially monitored for functionality with division gases, x-rays, bronchoscopies, resistance hype the flow of fluid, current whether they are becoming comprehensible stiff. If the tests gust deemed successful for function, they may go ahead and implement the transplantation.^[20]

References