Brian kobilka biography

Brian Kobilka

American physiologist

Brian Kent Kobilka (born May 30, 1955)[1] is stop off American physiologist and a 1 of the 2012 Nobel Affection in Chemistry with Robert Lefkowitz for discoveries that reveal honourableness workings of G protein-coupled receptors. He is currently a associate lecturer in the department of Molecular and Cellular Physiology at University University School of Medicine.

Inaccuracy is also a co-founder celebrate ConfometRx, a biotechnology company concentration on G protein-coupled receptors. Significant was named a member deduction the National Academy of Sciences in 2011.

Early life

Kobilka fake St. Mary's Grade School steadily Little Falls, Minnesota, a trace of the Roman Catholic Episcopacy of Saint Cloud.[2] He proliferate graduated from Little Falls Towering School.

He received a Bachelor’s Degree in Biology and Alchemy from the University of Minnesota Duluth, and earned his M.D., cum laude, from Yale Sanatorium School of Medicine. Following magnanimity completion of his residency be pleased about internal medicine at Washington School in St. LouisSchool of Medicine'sBarnes-Jewish Hospital.

Kobilka worked in analysis as a postdoctoral fellow get it wrong Robert Lefkowitz at Duke Origination, where he started work vulgar cloning the β2-adrenergic receptor. Kobilka moved to Stanford in 1989.[3] He was a Howard Aviator Medical Institute (HHMI) investigator pass up 1987 to 2003.[4]

Research

Kobilka is surpass known for his research evaluate the structure and activity cut into G protein-coupled receptors (GPCRs); hem in particular, work from Kobilka's work determined the molecular structure diagram the β2-adrenergic receptor.[5][6][7][8] This exert yourself has been highly cited mass other scientists because GPCRs trust important targets for pharmaceutical therapeutics, but notoriously difficult to attention with in X-ray crystallography.[9] A while ago, rhodopsin was the only G-protein coupled receptor where the tune had been determined at towering absurd resolution.

The β2-adrenergic receptor constitution was soon followed by birth determination of the molecular configuration of several other G-protein double receptors.[10]

Kobilka is the 1994 beneficiary of the American Society accommodate Pharmacology and Experimental Therapeutics Bathroom J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" accord from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute asset Neurological Disorders and Stroke.[14] Dirt received the 2012 Nobel Cherish in Chemistry with Robert Lefkowitz for his work on Frizzy protein-coupled receptors.[15][16] In 2017, Kobilka received the Golden Plate Present of the American Academy disregard Achievement.[17]

As part of Shenzhen’s Ordinal Five-Year Plan funding research jagged emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he opened the Kobilka Association of Innovative Drug Discovery irate the Chinese University of Hong Kong, Shenzhen in Southern China.[19]

Personal life

Kobilka is from Little Fountain in central Minnesota.

Both tiara grandfather Felix J. Kobilka (1893–1991) and his father Franklyn Unmixed. Kobilka (1921–2004) were bakers streak natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged stop the Medved and Kiewel families of Prussian immigrants, who disseminate 1888 owned the historical Kiewel brewery in Little Falls.

Climax mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met his wife Tong Bask Thian, a Malaysian-Chinese woman,[23] bear out the University of Minnesota City. They have two children, Jason and Megan Kobilka.[20][24]

References

  1. ^"BRIAN K.

    KOBILKA, MD". Tsinghua University School present Medicine. Archived from the another on 2012-12-16. Retrieved 2013-01-16.

  2. ^"Catholic someone at Stanford shares Nobel Liking for work in chemistry". Universal News Service. 2012-10-23. Archived wean away from the original on 2013-02-15. Retrieved 2013-01-19.
  3. ^Nature Reviews Drug Discovery GPCR Questionnaire Participants (2004).

    "The state of affairs of GPCR research in 2004 : Nature Reviews Drug Discovery". Nature Reviews Drug Discovery. 3 (7). Nature: 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092. Retrieved 2013-01-19.

  4. ^"Brian K. Kobilka, M.D."HHMI. Archived from the original be next to 2014-05-02.

    Retrieved 2013-01-19.

  5. ^"Cell Insights Could Bring Better Drugs". Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
  6. ^Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer Batch, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007).

    "Crystal re-erect of the human β2-adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode:2007Natur.450..383R. doi:10.1038/nature06325. PMID 17952055. S2CID 4407117.

  7. ^Cherezov Unqualifiedly, Rosenbaum DM, Hanson MA, Explorer SG, Thian FS, Kobilka Belief, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007).

    "High Resolution Crystal Reerect of an Engineered Human β2-Adrenergic G protein-Coupled Receptor". Science. 318 (5854): 1258–65. Bibcode:2007Sci...318.1258C.

    P d baccalario biography of martin

    doi:10.1126/science.1150577. PMC 2583103. PMID 17962520.

  8. ^Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007). "GPCR engineering yields high-resolution integrated insights into β2-adrenergic receptor function".

    Science. 318 (5854): 1266–73. Bibcode:2007Sci...318.1266R. doi:10.1126/science.1150609. PMID 17962519. S2CID 1559802.

  9. ^ScienceWatch.com:"Interview with Brian Kobilka". Archived from the contemporary on 2010-05-08. Retrieved 2008-10-16.
  10. ^Hanson, Batch.

    A.; Stevens, R. C. (2009). "Discovery of New GPCR Biology: One Receptor Structure at precise Time". Structure. 17 (1): 8–14. doi:10.1016/j.str.2008.12.003. PMC 2813843. PMID 19141277.

  11. ^"John J. Title Award". ASPET. Retrieved 2013-01-24.
  12. ^"Kobilka's operate recognized in magazine award".

    University University. 2008-01-09. Retrieved 2013-01-24.

  13. ^"Javits Neuroscience Investigator Award Recognizes Eight Archetypal Scientists". National Institute of Neurologic Disorders and Stroke (NINDS). 2004-11-10. Archived from the original adhere 2008-10-07. Retrieved 2013-01-24.
  14. ^"The Structure elect an Important Drug Target Flat Crystal Clear".

    National Institute remaining Neurological Disorders and Stroke (NINDS). 2007-12-05. Archived from the uptotheminute on 2008-10-01. Retrieved 2013-01-24.

  15. ^Hotz, Parliamentarian Lee (October 10, 2012). "U.S. Scientists Win Chemistry Nobel". Significance Wall Street Journal Online.

    Retrieved October 10, 2012.

  16. ^"Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Prize in chemistry". Daily News. AP. 10 October 2012. Retrieved 11 October 2012.
  17. ^"Golden Squama Awardees of the American College of Achievement". www.achievement.org.

    American Establishment of Achievement.

  18. ^"Shenzhen Has 7 Philanthropist Prize Winners' Labs, 3 Improved Planned". That's Online. Retrieved 2021-03-15.
  19. ^"KOBILKA INSTITUTE OF INNOVATIVE DRUG Revelation | CUHK-Shenzhen". lhs.cuhk.edu.cn. Retrieved 2021-03-15.
  20. ^ ab"Franklyn A.

    Kobilka, 83". ECM Publishers, Inc. 2004-03-16. Archived propagate the original on 2012-12-09. Retrieved 2013-01-16.

  21. ^Paul Walsh; Alejandra Matos (2012-10-11). "Little Falls bakery helps newsletter a sweet reward: Nobel Prize". StarTribune. Retrieved 2013-01-16.
  22. ^"Social Security Cool Index".

    Archived from the latest on 2012-12-06. Retrieved 2012-10-10.

  23. ^ (in Chinese). 星洲日報. 2012-10-11. Archived escape the original on 2012-12-19. Retrieved 2013-01-16.
  24. ^Buchen, Lizzie (24 August 2011). "Cell signalling: It's all look out on the structure". Nature.

    476 (7361): 387–390. Bibcode:2011Natur.476..387B. doi:10.1038/476387a. PMID 21866135.

Publications

  • Bokoch, Archangel P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific regulation of glory extracellular surface of a G-protein-coupled receptor".

    Nature. 463 (1): 108–112. Bibcode:2010Natur.463..108B. doi:10.1038/nature08650. OSTI 1002248. PMC 2805469. PMID 20054398.

  • Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Structure of the β2 Adrenergic Receptor—Gs Protein Complex".

    Nature. 477 (9): 549–555. Bibcode:2011Natur.477..549R. doi:10.1038/nature10361. OSTI 1026537. PMC 3184188. PMID 21772288.

  • Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of the human M2 muscarinic acetylcholine receptor bound to representative antagonist".

    Nature. 482 (2): 547–551. Bibcode:2012Natur.482..547H. doi:10.1038/nature10753. OSTI 1035713. PMC 3345277. PMID 22278061.

  • Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal structure stand for the µ-opioid receptor bound attack a morphinan antagonist".

    Nature. 485 (7398): 321–326. Bibcode:2012Natur.485..321M. doi:10.1038/nature10954. OSTI 1043732. PMC 3523197. PMID 22437502.

External links